Articles 2025

Boilard E, Burger D, Buzas E, Gresele P, Machlus KR, Mackman N, Siljander P, Nieuwland R. Deciphering Platelets: Are They Cells or an Evolved Form of Extracellular Vesicles? Circ Res. 2025 Feb 14;136(4):442-452. doi: 10.1161/CIRCRESAHA.124.324721. Epub 2025 Feb 13. PMID: 39946441.

Collins KE, Gilbert E, Mauduit V, Gaheer P, Elhassan EAE, Benson KA, Osman SM, Hill C, McKnight AJ, Maxwell AP, van der Most PJ, de Borst MH, Guan W, Jacobson PA, Israni AK, Keating BJ, Lord GM, Markkinen S, Helanterä I, Hyvärinen K, Partanen J, Madden SF, Storrar J, Sinha S, Kalra PA, Lanktree MB, Limou S, Cavalleri GL, Conlon PJ. Polygenic risk scores for eGFR are associated with age at kidney failure. J Nephrol. 2025 Mar 3. doi: 10.1007/s40620-025-02207-7. Epub ahead of print. PMID: 40029548.

Collins KE, Gilbert E, Mauduit V, Benson KA, Elhassan EAE, O’Seaghdha C, Hill C, McKnight AJ, Maxwell AP, van der Most PJ, de Borst MH, Guan W, Jacobson PA, Israni AK, Keating BJ, Lord GM, Markkinen S, Helanterä I, Hyvärinen K, Partanen J, Madden SF, Lanktree MB, Limou S, Cavalleri GL, Conlon PJ. Donor and Recipient Polygenic Risk Scores Influence Kidney Transplant Function. Transpl Int. 2025 Mar 4;38:14171. doi: 10.3389/ti.2025.14171. PMID: 40104404.

Höyhtyä M, Haaramo A, Nikkonen A, Ventin-Holmberg R, Agrawal N, Ritari J, Hickman B, Partanen J, Alapulli H, Tuokkola J, Salonen A, de Vos WM, Kolho KL. Fecal microbiota and genetics in pediatric-onset orofacial granulomatosis and Crohn´s disease. Sci Rep. 2025 Feb 19;15(1):6020. doi: 10.1038/s41598-025-90243-5. PMID: 39972069.

Ilvonen P, Susila S, Impola U, Pusa R, Helin T, Joutsi-Korhonen L, Laitinen S, Lauronen J, Ilmakunnas M. Extracellular vesicles in ageing cold-stored whole blood may not compensate for the decreasing haemostatic function in vitro. Transfus Med. 2025 Jan 24. doi: 10.1111/tme.13122. Epub ahead of print. PMID: 39865366.

Joo S, Dhaygude K, Krebs R, Holmström E, Puhka M, Laitinen S, Dellgren G, Magnusson J, Holmberg EC, Svahn J, Lund TK, Leuckfeld I, Raivio P, Helanterä I, Åberg F, Syrjälä SO, Nykänen AI, Lemström KB. Extracellular Vesicles in Lung Donor Plasma: Potential Indicators of Donor Organ Quality. J Thorac Cardiovasc Surg. 2025 Mar 19:S0022-5223(25)00210-7. doi: 10.1016/j.jtcvs.2025.03.012. Epub ahead of print. PMID: 40118141.

Liukkonen V, Semenova M, Hyvärinen K, Lauronen J, Partanen J, Arola J, Nordin A, Färkkilä M, Åberg F. Genetic Risk Factors for Steatotic Liver Disease After Liver Transplantation. Liver Int. 2025 Apr;45(4):e70067. doi: 10.1111/liv.70067. PMID: 40087975.

Lundgren S, Huuhtanen J, Keränen M, Feng X, Patel BA, Ryland GL, Fox LC, Bravo-Perez C, Clemente M, Kerr C, Walldin G, Dufva O, Zaimoku Y, Tuononen T, Myllymäki M, Ebeling F, Jokinen E, Heinonen M, Kasanen T, Klievink J, Lähteenmäki H, Jaatinen T, Kytölä S, Siitonen S, Dulau-Florea A, Braylan R, Heinäniemi M, Nakao S, Hellström-Lindberg E, Maciejewski JP, Blombery P, Young NS, Lähdesmäki H, Mustjoki S. Single-cell analysis of aplastic anemia reveals a convergence of NK and NK-like CD8⁺ T cells with a disease-associated TCR signature. Sci Transl Med. 2025 Feb 26;17(787):eadl6758. doi: 10.1126/scitranslmed.adl6758. Epub 2025 Feb 26. PMID: 40009697.

Luostarinen A, Vuorela A, Kerkelä E, Patrikoski M, Kotovuori A, Koski J, Ahoniemi J, Lähteenmäki K, Lehtisalo J, Oja T, Paavilainen H, Autio A, Nyman M, Nikoskelainen V, Kergourlay V, Elbasani E, van Veen B, Thotakura A, Monzo H, Ojala PM, Korhonen M, Hongisto H, Laitinen A. Establishing a GMP-compliant manufacturing process and phase-appropriate analytics for early development of a FiCAR T-cell product with a novel CAR spacer. Sci Rep. 2025 Mar 8;15(1):8093. doi: 10.1038/s41598-025-92736-9. PMID: 40057567.

Mustonen L, Nieminen JK, Koskela S, Kaunisto M, Kalso E, Tienari PJ, Harno H. HLA-Region Genetic Association Analysis of Breast Cancer Patients With and Without Persistent Postsurgical Neuropathic Pain. Eur J Pain. 2025 Apr;29(4):e70009. doi: 10.1002/ejp.70009. PMID: 40084918.

Pitkänen HH, Helin T, Khawaja T, Pietilä JP, Kajova M, Välimaa H, Vahlberg T, Ihalainen J, Vierikko A, Vapalahti O, Kantele A, Lassila R. Coagulation Profile of Convalescent Plasma Donors and Recipients. Clin Appl Thromb Hemost. 2025 Jan-Dec;31:10760296251317522. doi: 10.1177/10760296251317522. PMID: 39886886.

Susila S, Helin T, Joutsi-Korhonen L, Lauronen J, Ilmakunnas M. Quality of whole blood stored in room temperature for up to 5 days. Transfusion. 2025 Feb 5. doi: 10.1111/trf.18133. Epub ahead of print. PMID: 39908257.

Vlasov HE, Petäjä LM, Wilkman EM, Talvasto AT, Ilmakunnas MK, Raivio PM, Hiippala ST, Suojaranta RT, Juvonen TS, Pesonen EJ. Perioperative Bleeding Is Not an Independent Risk Factor for Acute Kidney Injury in On-pump Cardiac Surgery-A Post-hoc Analysis of a Randomized Clinical Trial. J Cardiothorac Vasc Anesth. 2025 Mar 6:S1053-0770(25)00205-8. doi: 10.1053/j.jvca.2025.03.006. Epub ahead of print. PMID: 40157892.

Wedenoja S, Ritari J, Partanen J, Kere J, Kolho KL. Enrichment of rare CFTR variants in Finnish patients with congenital chloride diarrhea. PLoS One. 2025 Feb 24;20(2):e0318249. doi: 10.1371/journal.pone.0318249. PMID: 39992989.

 

Consortium publications

The International Platelet Survey Investigators:

Ohto H, Flegel WA, van der Meer PF, Ngoma AM, Nollet KE, Choudhury N, Legler TJ; with the International Platelet Survey Investigators. The 2024 international survey of platelet products and practice. Transfus Apher Sci. 2025 Apr;64(2):104086. doi: 10.1016/j.transci.2025.104086. Epub 2025 Feb 11. PMID: 39970652.

 

 

The FinnGen Project:

Eghtedarian R, Tervi AM, Jones SE; FinnGen; Partinen M, Viippola E, Ollila HM. Narcolepsy as a potential risk factor for Schizophrenia. Transl Psychiatry. 2025 Feb 17;15(1):55. doi: 10.1038/s41398-025-03259-w. PMID: 39962082.

Hatzikotoulas K, Southam L, Stefansdottir L, Boer CG, McDonald ML, Pett JP, Park YC, Tuerlings M, Mulders R, Barysenka A, Arruda AL, Tragante V, Rocco A, Bittner N, Chen S, Horn S, Srinivasasainagendra V, To K, Katsoula G, Kreitmaier P, Tenghe AMM, Gilly A, Arbeeva L, Chen LG, de Pins AM, Dochtermann D, Henkel C, Höijer J, Ito S, Lind PA, Lukusa-Sawalena B, Minn AKK, Mola-Caminal M, Narita A, Nguyen C, Reimann E, Silberstein MD, Skogholt AH, Tiwari HK, Yau MS, Yue M, Zhao W, Zhou JJ, Alexiadis G, Banasik K, Brunak S, Campbell A, Cheung JTS, Dowsett J, Faquih T, Faul JD, Fei L, Fenstad AM, Funayama T, Gabrielsen ME, Gocho C, Gromov K, Hansen T, Hudjashov G, Ingvarsson T, Johnson JS, Jonsson H, Kakehi S, Karjalainen J, Kasbohm E, Lemmelä S, Lin K, Liu X, Loef M, Mangino M, McCartney D, Millwood IY, Richman J, Roberts MB, Ryan KA, Samartzis D, Shivakumar M, Skou ST, Sugimoto S, Suzuki K, Takuwa H, Teder-Laving M, Thomas L, Tomizuka K, Turman C, Weiss S, Wu TT, Zengini E, Zhang Y; arcOGEN Consortium; ARGO Consortium; DBDS Genomic Consortium; Estonian Biobank Research Team; FinnGen; Genes & Health Research Team; HUNT All-In Pain; Million Veteran Program; Regeneron Genetics Center; Ferreira MAR, Babis G, Baras A, Barker T, Carey DJ, Cheah KSE, Chen Z, Cheung JP, Daly M, de Mutsert R, Eaton CB, Erikstrup C, Furnes ON, Golightly YM, Gudbjartsson DF, Hailer NP, Hayward C, Hochberg MC, Homuth G, Huckins LM, Hveem K, Ikegawa S, Ishijima M, Isomura M, Jones M, Kang JH, Kardia SLR, Kloppenburg M, Kraft P, Kumahashi N, Kuwata S, Lee MTM, Lee PH, Lerner R, Li L, Lietman SA, Lotta L, Lupton MK, Mägi R, Martin NG, McAlindon TE, Medland SE, Michaëlsson K, Mitchell BD, Mook-Kanamori DO, Morris AP, Nabika T, Nagami F, Nelson AE, Ostrowski SR, Palotie A, Pedersen OB, Rosendaal FR, Sakurai-Yageta M, Schmidt CO, Sham PC, Singh JA, Smelser DT, Smith JA, Song YQ, Sørensen E, Tamiya G, Tamura Y, Terao C, Thorleifsson G, Troelsen A, Tsezou A, Uchio Y, Uitterlinden AG, Ullum H, Valdes AM, van Heel DA, Walters RG, Weir DR, Wilkinson JM, Winsvold BS, Yamamoto M, Zwart JA, Stefansson K, Meulenbelt I, Teichmann SA, van Meurs JBJ, Styrkarsdottir U, Zeggini E. Translational genomics of osteoarthritis in 1,962,069 individuals. Nature. 2025 Apr 9. doi: 10.1038/s41586-025-08771-z. Epub ahead of print. PMID: 40205036.

Joensuu L, Koivunen K, Tynkkynen NP, Palviainen T, Kaprio J; FinnGen Consortium; Klevjer M, Øvretveit K, Wisløff U, Bye A, Ekelund U, Sillanpää E. Genetic liability to sedentary behaviour and cardiovascular disease incidence in the FinnGen and HUNT cohorts. Br J Sports Med. 2025 Mar 26:bjsports-2024-109491. doi: 10.1136/bjsports-2024-109491. Epub ahead of print. PMID: 40139721.

Ottensmann L, Tabassum R, Ruotsalainen SE, Gerl MJ, Klose C, McCartney DL, Widén E; FinnGen; Simons K, Ripatti S, Vitart V, Hayward C, Pirinen M. Examining the link between 179 lipid species and 7 diseases using genetic predictors. 2025 Mar 28;114:105671. doi: 10.1016/j.ebiom.2025.105671. Epub ahead of print. PMID: 40157129.

Räsänen J, Helisalmi S, Heikkinen S, Raivo J, Korhonen VE, Martiskainen H, Junkkari A, Grenier-Boley B, Bellenguez C, Oinas M, Avellan C, Frantzen J, Kotkansalo A, Rinne J, Ronkainen A, Kauppinen M, von Und Zu Fraunberg M, Lönnrot K, Satopää J, Perola M, Koivisto AM, Julkunen V, Portaankorva AM, Mannermaa A, Soininen H, Jääskeläinen JE, Lambert JC, Eide PK; FinnGen; Palotie A, Kurki MI, Hiltunen M, Leinonen V, Lipponen A. Low prevalence of CWH43 variants among Finnish and Norwegian idiopathic normal pressure hydrocephalus patients: a cohort-based observational study. Fluids Barriers CNS. 2025 Feb 13;22(1):17. doi: 10.1186/s12987-025-00625-0. PMID: 39948543.

Weng LC, Rämö JT, Jurgens SJ, Khurshid S, Chaffin M, Hall AW, Morrill VN, Wang X, Nauffal V, Sun YV, Beer D, Lee S, Nadkarni GN, Duong T, Wang B, Czuba T, Austin TR, Yoneda ZT, Friedman DJ, Clayton A, Hyman MC, Judy RL, Skanes AC, Orland KM, Treu TM, Oetjens MT, Alonso A, Soliman EZ, Lin H, Lunetta KL, van der Pals J, Issa TZ, Nafissi NA, May HT, Leong-Sit P, Roselli C, Choi SH; FinnGen; Million Veteran Program; Regeneron Genetics Center; Khan HR, Knight S, Karlsson Linnér R, Bezzina CR, Ripatti S, Heckbert SR, Gaziano JM, Loos RJF, Psaty BM, Smith JG, Benjamin EJ, Arking DE, Rader DJ, Shah SH, Roden DM, Damrauer SM, Eckhardt LL, Roberts JD, Cutler MJ, Shoemaker MB, Haggerty CM, Cho K, Palotie A, Wilson PWF, Ellinor PT, Lubitz SA. The impact of common and rare genetic variants on bradyarrhythmia development. Nat Genet. 2025 Jan 2. doi: 10.1038/s41588-024-01978-2. Epub ahead of print. PMID: 39747593.