Articles 2025

Boilard E, Burger D, Buzas E, Gresele P, Machlus KR, Mackman N, Siljander P, Nieuwland R. Deciphering Platelets: Are They Cells or an Evolved Form of Extracellular Vesicles? Circ Res. 2025 Feb 14;136(4):442-452. doi: 10.1161/CIRCRESAHA.124.324721. Epub 2025 Feb 13. PMID: 39946441.

Collins KE, Gilbert E, Mauduit V, Gaheer P, Elhassan EAE, Benson KA, Osman SM, Hill C, McKnight AJ, Maxwell AP, van der Most PJ, de Borst MH, Guan W, Jacobson PA, Israni AK, Keating BJ, Lord GM, Markkinen S, Helanterä I, Hyvärinen K, Partanen J, Madden SF, Storrar J, Sinha S, Kalra PA, Lanktree MB, Limou S, Cavalleri GL, Conlon PJ. Polygenic risk scores for eGFR are associated with age at kidney failure. J Nephrol. 2025 Mar 3. doi: 10.1007/s40620-025-02207-7. Epub ahead of print. PMID: 40029548.

Höyhtyä M, Haaramo A, Nikkonen A, Ventin-Holmberg R, Agrawal N, Ritari J, Hickman B, Partanen J, Alapulli H, Tuokkola J, Salonen A, de Vos WM, Kolho KL. Fecal microbiota and genetics in pediatric-onset orofacial granulomatosis and Crohn´s disease. Sci Rep. 2025 Feb 19;15(1):6020. doi: 10.1038/s41598-025-90243-5. PMID: 39972069.

Ilvonen P, Susila S, Impola U, Pusa R, Helin T, Joutsi-Korhonen L, Laitinen S, Lauronen J, Ilmakunnas M. Extracellular vesicles in ageing cold-stored whole blood may not compensate for the decreasing haemostatic function in vitro. Transfus Med. 2025 Jan 24. doi: 10.1111/tme.13122. Epub ahead of print. PMID: 39865366.

Lundgren S, Huuhtanen J, Keränen M, Feng X, Patel BA, Ryland GL, Fox LC, Bravo-Perez C, Clemente M, Kerr C, Walldin G, Dufva O, Zaimoku Y, Tuononen T, Myllymäki M, Ebeling F, Jokinen E, Heinonen M, Kasanen T, Klievink J, Lähteenmäki H, Jaatinen T, Kytölä S, Siitonen S, Dulau-Florea A, Braylan R, Heinäniemi M, Nakao S, Hellström-Lindberg E, Maciejewski JP, Blombery P, Young NS, Lähdesmäki H, Mustjoki S. Single-cell analysis of aplastic anemia reveals a convergence of NK and NK-like CD8⁺ T cells with a disease-associated TCR signature. Sci Transl Med. 2025 Feb 26;17(787):eadl6758. doi: 10.1126/scitranslmed.adl6758. Epub 2025 Feb 26. PMID: 40009697.

Luostarinen A, Vuorela A, Kerkelä E, Patrikoski M, Kotovuori A, Koski J, Ahoniemi J, Lähteenmäki K, Lehtisalo J, Oja T, Paavilainen H, Autio A, Nyman M, Nikoskelainen V, Kergourlay V, Elbasani E, van Veen B, Thotakura A, Monzo H, Ojala PM, Korhonen M, Hongisto H, Laitinen A. Establishing a GMP-compliant manufacturing process and phase-appropriate analytics for early development of a FiCAR T-cell product with a novel CAR spacer. Sci Rep. 2025 Mar 8;15(1):8093. doi: 10.1038/s41598-025-92736-9. PMID: 40057567.

Mustonen L, Nieminen JK, Koskela S, Kaunisto M, Kalso E, Tienari PJ, Harno H. HLA-Region Genetic Association Analysis of Breast Cancer Patients With and Without Persistent Postsurgical Neuropathic Pain. Eur J Pain. 2025 Apr;29(4):e70009. doi: 10.1002/ejp.70009. PMID: 40084918.

Pitkänen HH, Helin T, Khawaja T, Pietilä JP, Kajova M, Välimaa H, Vahlberg T, Ihalainen J, Vierikko A, Vapalahti O, Kantele A, Lassila R. Coagulation Profile of Convalescent Plasma Donors and Recipients. Clin Appl Thromb Hemost. 2025 Jan-Dec;31:10760296251317522. doi: 10.1177/10760296251317522. PMID: 39886886.

Susila S, Helin T, Joutsi-Korhonen L, Lauronen J, Ilmakunnas M. Quality of whole blood stored in room temperature for up to 5 days. Transfusion. 2025 Feb 5. doi: 10.1111/trf.18133. Epub ahead of print. PMID: 39908257.

Wedenoja S, Ritari J, Partanen J, Kere J, Kolho KL. Enrichment of rare CFTR variants in Finnish patients with congenital chloride diarrhea. PLoS One. 2025 Feb 24;20(2):e0318249. doi: 10.1371/journal.pone.0318249. PMID: 39992989.

Consortium publications

The International Platelet Survey Investigators:

Ohto H, Flegel WA, van der Meer PF, Ngoma AM, Nollet KE, Choudhury N, Legler TJ; with the International Platelet Survey Investigators. The 2024 international survey of platelet products and practice. Transfus Apher Sci. 2025 Apr;64(2):104086. doi: 10.1016/j.transci.2025.104086. Epub 2025 Feb 11. PMID: 39970652.

 

The FinnGen Project:

Eghtedarian R, Tervi AM, Jones SE; FinnGen; Partinen M, Viippola E, Ollila HM. Narcolepsy as a potential risk factor for Schizophrenia. Transl Psychiatry. 2025 Feb 17;15(1):55. doi: 10.1038/s41398-025-03259-w. PMID: 39962082.

Räsänen J, Helisalmi S, Heikkinen S, Raivo J, Korhonen VE, Martiskainen H, Junkkari A, Grenier-Boley B, Bellenguez C, Oinas M, Avellan C, Frantzen J, Kotkansalo A, Rinne J, Ronkainen A, Kauppinen M, von Und Zu Fraunberg M, Lönnrot K, Satopää J, Perola M, Koivisto AM, Julkunen V, Portaankorva AM, Mannermaa A, Soininen H, Jääskeläinen JE, Lambert JC, Eide PK; FinnGen; Palotie A, Kurki MI, Hiltunen M, Leinonen V, Lipponen A. Low prevalence of CWH43 variants among Finnish and Norwegian idiopathic normal pressure hydrocephalus patients: a cohort-based observational study. Fluids Barriers CNS. 2025 Feb 13;22(1):17. doi: 10.1186/s12987-025-00625-0. PMID: 39948543.

Weng LC, Rämö JT, Jurgens SJ, Khurshid S, Chaffin M, Hall AW, Morrill VN, Wang X, Nauffal V, Sun YV, Beer D, Lee S, Nadkarni GN, Duong T, Wang B, Czuba T, Austin TR, Yoneda ZT, Friedman DJ, Clayton A, Hyman MC, Judy RL, Skanes AC, Orland KM, Treu TM, Oetjens MT, Alonso A, Soliman EZ, Lin H, Lunetta KL, van der Pals J, Issa TZ, Nafissi NA, May HT, Leong-Sit P, Roselli C, Choi SH; FinnGen; Million Veteran Program; Regeneron Genetics Center; Khan HR, Knight S, Karlsson Linnér R, Bezzina CR, Ripatti S, Heckbert SR, Gaziano JM, Loos RJF, Psaty BM, Smith JG, Benjamin EJ, Arking DE, Rader DJ, Shah SH, Roden DM, Damrauer SM, Eckhardt LL, Roberts JD, Cutler MJ, Shoemaker MB, Haggerty CM, Cho K, Palotie A, Wilson PWF, Ellinor PT, Lubitz SA. The impact of common and rare genetic variants on bradyarrhythmia development. Nat Genet. 2025 Jan 2. doi: 10.1038/s41588-024-01978-2. Epub ahead of print. PMID: 39747593.