Articles 2020

​Adnan-Awad S, Dufva O, Ianevski A, Ghimire B, Koski J, Maliniemi P, Thomson D, Schreiber A, Heckman CA, Koskenvesa P, Korhonen M, Porkka K, Branford S, Aittokallio T, Kankainen M, Mustjoki S. RUNX1 mutations in blast-phase chronic myeloid leukemia associate with distinct phenotypes, transcriptional profiles, and drug responses. Leukemia. 2021 Apr;35(4):1087-1099. Epub 2020 Aug 11. PMID: 32782381

Bäckman S, Valkeajärvi A, Korkalainen P, Arvas M, Castrén J. Venous sample is superior to repeated skin-prick testing in blood donor haemoglobin second-line screening. Vox Sang. 2020 Nov;115(8):617-623. PMID: 32314403

Dufva O, Koski J, Maliniemi P, Ianevski A, Klievink J, Leitner J, Polonen P, Hohtari H, Saeed K, Hannunen T, Ellonen P, Steinberger P, Kankainen M, Aittokallio T, Keranen MAI, Korhonen M, Mustjoki S. Integrated drug profiling and CRISPR screening identify essential pathways for CAR T cell cytotoxicity. Blood 135:597-609, 2020 (IF 16,6)

Goldman M, Townsend M, Magnussen K, Lozano M, Nissen-Meyer LS, Lee CK, Leung JN, Takanashi M, McKay J, Kvist M, Robitaille N, Deschênes J, Di Angelantonio E, McMahon A, Roberts D, Maghsudlu M, Castrén J, Tiberghien P, Woimant G, Morel P, Kamel H, Bravo M, Shinhar E, Gendelman V, Raz H, Wendel S, Fachini R, Quee F, van den Hurk K, Wiersum J, Grima K, Speedy J, Bruun M, Dunbar N. Vox Sanguinis International Forum on Mitigation Strategies to Prevent Faint and Pre-faint Adverse Reactions in Whole Blood Donors: Summary. Vox Sang. 2021 Mar;116(3):351-359. Epub 2020 Nov 27. PMID: 33245787

Holopainen M, Impola, U, Lehenkari, P, Laitinen S, Kerkelä, E. Human Mesenchymal Stromal Cell Secretome Promotes the Immunoregulatory Phenotype and Phagocytosis Activity in Human Macrophages. Cells 2020 Sep 22;9(9):E2142. PMID: 32972000

Hyvärinen K, Koskela S, Niittyvuopio R, Nihtinen A, Volin L, Salmenniemi U, Putkonen M, Buno I, Gallardo D, Itälä-Remes M, Partanen J, Ritari J. Meta-analysis of genome-wide association and gene expression studies implicates donor T cell function and cytokine pathways in acute GvHD. Front Immunol. 2020 Feb 3;11:19. PMID: 32117222

Jalanka J, Cheng J, Hiippala K, Ritari J, Salojärvi J, Ruuska T, Kalliomäki M, Satokari R. Colonic Mucosal Microbiota and Association of Bacterial Taxa with the Expression of Host Antimicrobial Peptides in Pediatric Ulcerative Colitis. Int J Mol Sci. 2020;21(17):E6044. PMID: 32842596

Jokiniemi A, Kuusipalo L, Ritari J, Koskela S, Partanen J, Kekäläinen J. Gamete-level immunogenetic incompatibility in humans-towards deeper understanding of fertilization and infertility? Heredity (Edinb). 2020 Nov;125(5):281-289. PMID: 32747723

Jokiniemi A, Magris M, Ritari J, Kuusipalo L, Lundgren T, Partanen J, Kekäläinen J. Post-copulatory genetic matchmaking: HLA-dependent effects of cervical mucus on human sperm function. Proc Biol Sci. 2020;287(1933):20201682. PMID: 32811307

Koponen A, Kerkelä E, Rojalin T, Lázaro-Ibáñez E, Suutari T, Saari HO, Siljander P, Yli-Perttula M, Laitinen S, Viitala T. Label-Free Characterization and Real-Time Monitoring of Cell Uptake of Extracellular Vesicles. Biosens Bioelectron. 2020 Aug 15;168:112510. PMID: 32877783

Larsen MD, de Graaf EL, Sonneveld ME, Plomp HR, Nouta J, Hoepel W, Chen HJ, Linty F, Visser R, Brinkhaus M, Šuštić T, de Taeye SW, Bentlage AEH, Toivonen S, Koeleman CAM, Sainio S, Kootstra NA, Brouwer PJM, Geyer CE, Derksen NIL, Wolbink G, de Winther M, Sanders RW, van Gils MJ, de Bruin S, Vlaar APJ; Amsterdam UMC COVID-19 biobank study group, Rispens T, den Dunnen J, Zaaijer HL, Wuhrer M, Ellen van der Schoot C, Vidarsson G. Afucosylated IgG characterizes enveloped viral responses and correlates with COVID-19 severity. Science. 2021 Feb 26;371(6532):eabc8378. Epub 2020 Dec 23. PMID: 33361116

Lehtisalo M, Keskitalo JE, Tornio A, Lapatto-Reiniluoto O, Deng F, Jaatinen T, Viinamäki J, Neuvonen M, Backman JT, Niemi M. Febuxostat, But Not Allopurinol, Markedly Raises the Plasma Concentrations of the Breast Cancer Resistance Protein Substrate Rosuvastatin. Clin Transl Sci. 2020 Nov;13(6):1236-1243. Epub 2020 May 26. PMID: 32453913

Mikkelsen C, Mori G, van Walraven SM, Castrén J, Zahra S, MacLennan S, Seidel K, Fontana S, Veropalumbo E, Cannata L, Pupella S, Kvist M, Happel M, Korkalainen P, Wulff B, Fernandez-Sojo J, Eguizabal C, Urbano F, Vesga MA, Pozenel P, van Kraaij M, Hansen MB, Slot E, Ullum H. Putting the spotlight on donation-related risks and donor safety – are we succeeding in protecting donors? Vox Sang. 2021 Mar;116(3):313-323. PMID: 33103801

Mikkelsen C, Mori G, van Walraven SM, Castrén J, Zahra S, MacLennan S, Seidel K, Fontana S, Veropalumbo E, Cannata L, Pupella S, Kvist M, Happel M, Korkalainen P, Chandrasekar A, Paulus U, Bokhorst A, Wulff B, Fernandez‐Sojo J, Eguizabal C, Urbano F, Vesga MA, van Kraaij M, Merz EM, van den Hurk K, Hansen MB, Slot E, Ullum H. How donor selection criteria can be evaluated with limited scientific evidence: lessons learned from the TRANSPOSE project. Vox Sang. 2021 Mar;116(3):342-350. PMID: 33191514

Partanen J, Hyvärinen K, Bickeböller H, Bogunia-Kubik K, Crossland RE, Ivanova M, Perutelli F, Dressel R. Review of genetic variation as a predictive biomarker for chronic Graft-versus-Host-Disease after allogeneic stem cell transplantation. Front Immunol. 2020 Oct 19;11:575492. PMID: 33193367

Ritari J, Hyvärinen K, Clancy J; FinnGen, Partanen J, Koskela S. Increasing accuracy of HLA imputation by a population-specific reference panel in a FinnGen biobank cohort. NAR Genom Bioinform. 2020 May 6;2(2):lqaa030. PMID: 33575586

Seppälä LK, Vettenranta K, Leinonen MK, Tommiska V, Madanat-Harjuoja LM. Preterm birth, neonatal therapies and the risk of childhood cancer. Int J Cancer. 2021 May 1;148(9):2139-2147. Epub 2020 Nov 11. PMID: 33128776

Tammi SM, Tounsi WA, Sainio S, Kiernan M, Avent ND, Madgett TE, Haimila K. Next-generation sequencing of 35 RHD variants in 16,253 serologically D negative pregnant women in Finnish population. Blood Adv. 2020 4(20):4994–5001. PMID: 33057632

Tarvonen M, Hovi P, Sainio S, Vuorela P, Andersson S, Teramo K. Intrapartum zigzag pattern of fetal heart rate is an early sign of fetal hypoxia: a large obstetric retrospective cohort study. Acta Obstet Gynecol Scand. 2021 Feb;100(2):252-262. Epub 2020 Oct 15. PMID: 32981037

Zalpuri S, Romeijn B, Allara E, Goldman M, Kamel H, Gorlin J, Vassallo R, Grégoire Y, Goto N, Flanagan P, Speedy J, Buser A, Kutner JM, Magnussen K, Castrén J, Culler L, Sussmann H, Prinsze FJ, Belanger K, Compernolle V, Tiberghien P, Cardenas JM, Gandhi MJ, West KA, Lee CK, James S, Wells D, Sutor LJ, Wendel S, Coleman M, Seltsam A, Roden K, Steele WR, Bohonek M, Alcantara R, Di Angelantonio E, van den Hurk K; BEST Collaborative Study Group. Variations in hemoglobin measurement and eligibility criteria across blood donation services are associated with differing low-hemoglobin deferral rates: a BEST Collaborative study. Transfusion. 2020 Mar;60(3):544-552. PMID: 32034925

Other publications

Ihalainen J & Salonen J. Verensiirtohoidon kehittämiseen tarvitaan kansallista tiedonhallintaa. Duodecim 2020;136(23):2563-5. JUFO 1. https://www.duodecimlehti.fi/lehti/2020/23/duo15926

Jernman R, Aitokallio-Tallberg A, Kauppinen T, Stefanovic V, Sainio S. Kohdunsisäinen punasolusiirto. Duodecim 2020;136(21):2393-400. JUFO 1. https://www.duodecimlehti.fi/lehti/2020/21/duo15854

Sainio S & Kuosmanen M. Yli 50 vuotta raskausimmunisaatioiden ehkäisyä ja seulontaa Veripalvelussa. Duodecim 2020;136(21):2321-3. JUFO 1. https://www.duodecimlehti.fi/lehti/2020/21/duo15862

Consortium publications

Bao EL, Nandakumar SK, Liao X, Bick AG, Karjalainen J, Tabaka M, Gan OI, Havulinna AS, Kiiskinen TTJ, Lareau CA, de Lapuente Portilla AL, Li B, Emdin C, Codd V, Nelson CP, Walker CJ, Churchhouse C, de la Chapelle A, Klein DE, Nilsson B, Wilson PWF, Cho K, Pyarajan S, Gaziano JM, Samani NJ; FinnGen; 23andMe Research Team, Regev A, Palotie A, Neale BM, Dick JE, Natarajan P, O’Donnell CJ, Daly MJ, Milyavsky M, Kathiresan S, Sankaran VG. Inherited myeloproliferative neoplasm risk affects haematopoietic stem cells. Nature. 2020 Oct;586(7831):769-775. PMID: 33057200

Kiiskinen T, Mars NJ, Palviainen T, Koskela J, Rämö JT, Ripatti P, Ruotsalainen S; FinnGen, GSCAN Consortium, Palotie A, Madden PAF, Rose RJ, Kaprio J, Salomaa V, Mäkelä P, Havulinna AS, Ripatti S. Genomic prediction of alcohol-related morbidity and mortality. Transl Psychiatry. 2020 Jan 21;10(1):23. PMID: 32066667

Mars N, Koskela JT, Ripatti P, Kiiskinen TTJ, Havulinna AS, Lindbohm JV, Ahola-Olli A, Kurki M, Karjalainen J, Palta P; FinnGen, Neale BM, Daly M, Salomaa V, Palotie A, Widén E, Ripatti S. Polygenic and clinical risk scores and their impact on age at onset and prediction of cardiometabolic diseases and common cancers. Nat Med. 2020 Epub Apr 7. PMID: 32273609

Mars N, Widén E, Kerminen S, Meretoja T, Pirinen M, Della Briotta Parolo P, Palta P; FinnGen, Palotie A, Kaprio J, Joensuu H, Daly M, Ripatti S. The role of polygenic risk and susceptibility genes in breast cancer over the course of life. Nat Commun. 2020 Dec 14;11(1):6383. PMID: 33318493

Ripatti P, Rämö JT, Mars NJ, Fu Y, Lin J, Söderlund S, Benner C, Surakka I, Kiiskinen T, Havulinna AS, Palta P, Freimer NB, Widén E, Salomaa V, Tukiainen T, Pirinen M, Palotie A, Taskinen MR, Ripatti S; FinnGen. Polygenic Hyperlipidemias and Coronary Artery Disease Risk. Circ Genom Precis Med. 2020 Apr;13(2):e002725. PMID: 32154731

Rodriguez BAT, Bhan A, Beswick A, Elwood PC, Niiranen TJ, Salomaa V; FinnGen Study, Trégouët DA, Morange PE, Civelek M, Ben-Shlomo Y, Schlaeger T, Chen MH, Johnson AD. A Platelet Function Modulator of Thrombin Activation Is Causally Linked to Cardiovascular Disease and Affects PAR4 Receptor Signaling. Am J Hum Genet. 2020 Aug 6;107(2):211-221. PMID: 32649856

Ruotsalainen SE, Partanen JJ, Cichonska A, Lin J, Benner C, Surakka I; FinnGen, Reeve MP, Palta P, Salmi M, Jalkanen S, Ahola-Olli A, Palotie A, Salomaa V, Daly MJ, Pirinen M, Ripatti S, Koskela J. An expanded analysis framework for multivariate GWAS connects inflammatory biomarkers to functional variants and disease. Eur J Hum Genet. 2020 Oct 27. Epub ahead of print. PMID: 33110245

Sakaue S, Kanai M, Karjalainen J, Akiyama M, Kurki M, Matoba N, Takahashi A, Hirata M, Kubo M, Matsuda K, Murakami Y; FinnGen, Daly MJ, Kamatani Y, Okada Y. Trans-biobank analysis with 676,000 individuals elucidates the association of polygenic risk scores of complex traits with human lifespan. Nat Med. 2020 Epub Mar 23. PMID: 32251405

Tanigawa Y, Wainberg M, Karjalainen J, Kiiskinen T, Venkataraman G, Lemmelä S, Turunen JA, Graham RR, Havulinna AS, Perola M, Palotie A; FinnGen, Daly MJ, Rivas MA. Rare protein-altering variants in ANGPTL7 lower intraocular pressure and protect against glaucoma. PLoS Genet. 2020 May 5;16(5):e1008682. PMID: 32369491

Vuori MA, Laukkanen JA, Pietilä A, Havulinna AS, Kähönen M, Salomaa V, Niiranen TJ; FinnGen investigators. The validity of heart failure diagnoses in the Finnish Hospital Discharge Register. Scand J Public Health. 2020 Feb;48(1):20-28. PMID: 31068116