SELECTED PUBLICATIONS

The foundation of the FRCBS research and development activity is the pioneering work on population genetics by Professor Harri Nevanlinna and on interferons by Professor Kari Cantell. Research on stem cell and solid organ transplantation has been carried out in the HLA laboratory and Cord Blood Bank by a number of scientists, producing hundreds of scientific publications. In total, more than 50 PhD theses have been done at the FRCBS. These are only the five selected publications of our top experts.

Matti Korhonen

1. Lahdelma L, Oja S, Korhonen M, Andersson LC. Clozapine is cytotoxic to primary cultures of human bone marrow mesenchymal stromal cells. J Clin Psychopharmacol. 30(4):461-3, 2010. IF 4.4

2. Sillat T, Pollanen R, Lopes J, Porola P, Ma G, Korhonen M, Konttinen Y. Intracrine androgenic apparatus in human bone marrow stromal cells. J Cell Mol Med, 13 (9b):3296-302, 2009. IF 6.7

3. Peura M, Bizik J, Noro A, Korhonen M, Pätilä T, Vento A, Vaheri A, Alitalo R, Vuola J, Harjula A, Kankuri E. Bone marrow mesenchymal stem cells undergo nemosis and induce keratinocyte wound healing utilizing hgf/c-met/pi3k pathway. Wound Repair Regen, 17:569-77, 2009. IF 2.4

4. Takkunen M, Grenman R, Hukkanen M, Korhonen M, de Herreros AG, Virtanen I. Snail-dependent and –independent epithelial-mesenchymal transformation in oral squamous carcinoma cells. J Histochem Cytochem 54:1263-75, 2006. IF 2.3

5. Mandelin J, Hukkanen M, Li T-F, Korhonen M, Liljeström M, Sillat T, Hanemaaijer R, Salo J, Santavirta S, Konttinen Y. Human osteoblasts produce cathepsin K. Bone 38:769-77, 2006. IF 4.0
 

Saara Laitinen

1. Alm J J, Koivu H AM, Heino T, Hentunen T, Laitinen S and Aro H T (In Press, 2010). Circulating plastic adherent mesenchymal stem cells in aged hip fracture patients. J Orth Res

2. Laitinen, A., Nystedt, J., and Laitinen, S. (In Press, 2010). The Isolation and Culture of Human Cord Blood-Derived Mesenchymal Stem Cells Under Hypoxic Conditions. Humana Press: Mesenchymal Stem Cell Assays and Applications

3. Takatalo, M., Jarvinen, E., Laitinen, S., Thesleff, I., and Ronnholm, R. (2008). Expression of the novel Golgi protein GoPro49 is developmentally regulated during mesenchymal differentiation. Dev. Dyn. 237, 2243-2255.

4. Laitinen, S., Fontaine, C., Fruchart, J., and Staels, B. (2005). The role of the orphan nuclear receptor Rev-Erbα in adipocyte differentiation and function. Biochimie 87, 21-25.

5. Laitinen, S., Lehto, M., Lehtonen, S., Hyvarinen, K., Heino, S., Lehtonen, E., Ehnholm, C., Ikonen, E., and Olkkonen, V.M. (2002). ORP2, a homolog of oxysterol binding protein, regulates cellular cholesterol metabolism. J. Lipid Res. 43, 245-255.

Jaana Mättö

1. Mättö J, Maukonen J, Alakomi H-L, Suihko M-L, Saarela M. Influence of Oral Doxycycline Therapy on the Diversity and Antibiotic Susceptibility of Human Intestinal Bifidobacterial Population. J. Appl. Microbiol, 2008: 105: 279-289.

2. Mättö J, van Hoek AHAM, Domig KJ, Saarela M, Floréz AB, Brockmann E, Amtmann E, Mayo B, Aarts HJM, Danielsen M. Susceptibility of bifidobacteria to selected antibiotics as determined by the Etest method. Int Dairy J. 2007: 17: 1123-1131.

3. Saarela M, von Wright A, Vilpponen-Salmela T, Maukonen J, Patterson AJ, Scott KP, Hämynen H, Mättö J. Tetracycline susceptibility of the ingested Lactobacillus acidophilus LaCH-5 and Bifidobacterium animalis subsp. lactis Bb-12 strains during antibiotic/probiotic intervention. Int. J. Antimicrob. Agents. 2007: 29:271-280.

4. Malinen E, Rinttilä T, Kajander K, Mättö J, Kassinen A, Krogius L, Saarela M, Korpela R, Palva A. Analysis of the fecal microbiota of irritable bowel syndrome patients and healthy controls with real-time PCR. Am J Gastroenterol 2005: 100: 373-382.

5. Mättö J, Maunuksela L, Kajander K, Palva A, Korpela R, Kassinen A, Saarela M. Composition and temporal stability of gastrointestinal microbiota in irritable bowel syndrome – a longitudinal study in IBS and control subjects. FEMS Immunol Med Microbiol 2005: 43: 213-222.

Johanna Nystedt

1. Nystedt J, Anderson H, Hirvonen T, Impola U, Jaatinen T, Heiskanen A, Blomqvist M, Satomaa T, Natunen J, Saarinen J, Lehenkari P, Valmu L, Laine J.Human CMP-N-acetylneuraminic acid hydroxylase is a novel stem cell marker linked to stem cell-specific mechanisms. Stem Cells. 2010 Feb;28(2):258-67. PubMed PMID:19890979.

2. Koponen JK, Kekarainen T, E Heinonen S, Laitinen A, Nystedt J, Laine J, Ylä-Herttuala S. Umbilical cord blood-derived progenitor cells enhance muscle regeneration in mouse hindlimb ischemia model. Mol Ther. 2007 Dec;15(12):2172-7. Epub 2007 Sep 18. PubMed PMID: 17878901.

3. Nystedt J, Mäkinen S, Laine J, Jolkkonen J. Human cord blood CD34+ cells and behavioral recovery following focal cerebral ischemia in rats. Acta Neurobiol Exp. 2006;66(4):293-300. PubMed PMID: 17265691.

4. Mäkinen S, Kekarainen T, Nystedt J, Liimatainen T, Huhtala T, Närvänen A, Laine J, Jolkkonen J. Human umbilical cord blood cells do not improve sensorimotor or cognitive outcome following transient middle cerebral artery occlusion in rats. Brain Res. 2006 Dec 6;1123(1):207-15. Epub 2006 Oct 30. PubMed PMID: 17070789.

5. Nystedt JM, Lemberg K, Lintunen M, Mustonen K, Holma R, Kontinen VK, Kalso E, Panula P. Pain- and morphine-associated transcriptional regulation of neuropeptide FF and the G-protein-coupled NPFF2 receptor gene. Neurobiol Dis. 2004 Jun;16(1):254-62. PubMed PMID: 15207282.

Jukka Partanen

1. McCarroll SA, Bradner JE, Turpeinen H, Volin L, Martin PJ, Chilewski SD, Antin JH, Lee SJ, Ruutu T, Storer B, Warren EH,  Zhang B, Ping Zhao L, Ginsburg D, Soiffer RJ, Partanen J, Hansen JA, Ritz J, Palotie A, Altshuler D. Donor-recipient mismatch for common gene deletion polymorphisms in graft-versus-host disease. Nature Genetics 2009; 41:1341-1345.

2. Turpeinen H, Volin L, Nikkinen L, Ojala P, Palotie A, Saarela J, Partanen J. Genetic Similarity of Chromosome 6 between Patients Receiving Hematopoietic Stem Cell Transplantation and HLA Matched Sibling Donors. Hematologica 2009;94:528-35.

3. Huang T-S, Hsieh J-Y, Wu Y-S, Jen C-H, Tsuang Y-H, Chiou S-H, Partanen J, Anderson H, Jaatinen T, Yu Y-H, Wang H-W. Functional network reconstruction reveals somatic stemness genetic maps and dedifferentiation-like transcriptome reprogramming induced by GATA2. Stem Cells 2008; 26:1186-201. (Epub 2008 Feb 28).

4. Olkinuora H, Talvensaari K, Kaartinen T, Siitonen S, Saarinen-Pihkala, U, Partanen J, Vettenranta K. T cell regeneration in pediatric stem cell transplantation. Bone Marrow Transplantation 2007; 39: 149-156.

5. Jaatinen T, Hemmoranta H, Hautaniemi S, Niemi J, Nicorici D, Laine J, Yli-Harja O, Partanen J. Global gene expression profile of human cord blood-derived CD133+ cells. Stem Cells 2006; 24: 631-641.

Leena Valmu

1. Valmu, L., Kalkkinen, N., Husa, A. and Rye, P. D. (2005) Differential susceptibility of transferrin glycoforms to chymotrypsin: a potential approach to the detection of carbohydrate deficient transferrin. Biochemistry 44, 16007-16013.

2. Valmu, L., Alfthan, H., Hotakainen, K., Birken, S. and Stenman, U-H. (2006) Site-specific glycan analysis on human chorionic ganadotropin β-subunit from malignancy and pregnancy by liquid chromatography-electrospray mass spectrometry. Glycobiology 16, 1207-1218

3. Itkonen, O., Helin, J., Saarinen, J., Kalkkinen, N., Ivanov, K.I., Stenman, U-H. and Valmu, L. (2008) Mass spectrometric detection of tyrosine sulfation in human pancreatic trypsinogens, but not in tumor-associated trypsinogen. FEBS Journal 275, 289-301

4. Heiskanen, A., Hirvonen, T., Salo, H., Impola, U., Olonen, A., Laitinen, A., Tiitinen, S., Natunen, S., Aitio, O., Miller-Podraza, H., Wuhrer, M., Deelder, A., Natunen, J., Lainen, J., Lehenkari, P., Saarinen, J., Satomaa, T. and Valmu, L. (2009) Glycomics of bone marrow-derived mesenchymal stem cells can be used to evaluate their cellular differentiation stage. Glycoconj J 26, 367-384.

5. Nystedt J, Anderson H, Hirvonen T, Impola U, Jaatinen T, Heiskanen A, Blomqvist M, Satomaa T, Natunen J, Saarinen J, Lehenkari P, Valmu L and Laine J (2010) Human CMP-N-acetylneuraminic acid hydroxylase (CMAH) is a Novel Stem Cell Marker Linked to Stem Cell-Specific Mechanisms. Stem Cells 28:258-267

All the scientific publications of FRCBS